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February 13, 2012: Our new research article appeared in Nature Structural and Molecular Biology

Our new paper “A novel actin binding site of myosin required for effective muscle contraction” just appeared in NSMB. The paper deals with the conserved actin-binding region of myosin named the ‘activation loop’. It interacts with actin, accelerateing the movement of the relay, stimulating myosin’s ATPase activity. This interaction results in efficient force generation, but it is not essential for the unloaded motility, as we demonstrated in vivo using transgenic Caenorhabditis elegans strains.

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